Nature Communications (Feb 2021)

Optical tweezers-controlled hotspot for sensitive and reproducible surface-enhanced Raman spectroscopy characterization of native protein structures

  • Xin Dai,
  • Wenhao Fu,
  • Huanyu Chi,
  • Vince St. Dollente Mesias,
  • Hongni Zhu,
  • Cheuk Wai Leung,
  • Wei Liu,
  • Jinqing Huang

DOI
https://doi.org/10.1038/s41467-021-21543-3
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 9

Abstract

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It is currently challenging to identify protein structures at low concentrations. Here the authors report optical tweezers-coupled Raman spectroscopy to generate tunable and reproducible SERS enhancements with single-molecule level sensitivity and use the method to detect protein structural features.