Nature Communications (Mar 2022)
Genetic variation of macronutrient tolerance in Drosophila melanogaster
- E. Havula,
- S. Ghazanfar,
- N. Lamichane,
- D. Francis,
- K. Hasygar,
- Y. Liu,
- L. A. Alton,
- J. Johnstone,
- E. J. Needham,
- T. Pulpitel,
- T. Clark,
- H. N. Niranjan,
- V. Shang,
- V. Tong,
- N. Jiwnani,
- G. Audia,
- A. N. Alves,
- L. Sylow,
- C. Mirth,
- G. G. Neely,
- J. Yang,
- V. Hietakangas,
- S. J. Simpson,
- A. M. Senior
Affiliations
- E. Havula
- Charles Perkins Centre, The University of Sydney
- S. Ghazanfar
- Charles Perkins Centre, The University of Sydney
- N. Lamichane
- Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki
- D. Francis
- Charles Perkins Centre, The University of Sydney
- K. Hasygar
- Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki
- Y. Liu
- Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki
- L. A. Alton
- School of Biological Sciences, Monash University
- J. Johnstone
- School of Biological Sciences, Monash University
- E. J. Needham
- Charles Perkins Centre, The University of Sydney
- T. Pulpitel
- Charles Perkins Centre, The University of Sydney
- T. Clark
- Charles Perkins Centre, The University of Sydney
- H. N. Niranjan
- Charles Perkins Centre, The University of Sydney
- V. Shang
- Charles Perkins Centre, The University of Sydney
- V. Tong
- Charles Perkins Centre, The University of Sydney
- N. Jiwnani
- Charles Perkins Centre, The University of Sydney
- G. Audia
- Charles Perkins Centre, The University of Sydney
- A. N. Alves
- School of Biological Sciences, Monash University
- L. Sylow
- Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen
- C. Mirth
- School of Biological Sciences, Monash University
- G. G. Neely
- Charles Perkins Centre, The University of Sydney
- J. Yang
- Charles Perkins Centre, The University of Sydney
- V. Hietakangas
- Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki
- S. J. Simpson
- Charles Perkins Centre, The University of Sydney
- A. M. Senior
- Charles Perkins Centre, The University of Sydney
- DOI
- https://doi.org/10.1038/s41467-022-29183-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Responses to diet composition may be linked to susceptibility to metabolic diseases such as type 2 diabetes. Here the authors report that Drosophila melanogaster displays genetic variation in survival on different diets and describe the importance for JNK-pathway and a conserved orphan nuclear hormone receptor tailless in regulating sugar tolerance.
