Synthesis of Hierarchically Porous Bioactive Glass and Its Mineralization Activity
Jiawei Liu,
Guo Du,
Hongda Yu,
Xueyin Zhang,
Tiehong Chen
Affiliations
Jiawei Liu
Interdisciplinary Science Center, Key Laboratory of Advanced Energy Materials Chemistry (MOE), Institute of New Catalytic Materials Science, School of Materials Science and Engineering, Smart Sensing, Nankai University, Tianjin 300350, China
Guo Du
Interdisciplinary Science Center, Key Laboratory of Advanced Energy Materials Chemistry (MOE), Institute of New Catalytic Materials Science, School of Materials Science and Engineering, Smart Sensing, Nankai University, Tianjin 300350, China
Hongda Yu
Interdisciplinary Science Center, Key Laboratory of Advanced Energy Materials Chemistry (MOE), Institute of New Catalytic Materials Science, School of Materials Science and Engineering, Smart Sensing, Nankai University, Tianjin 300350, China
Xueyin Zhang
Interdisciplinary Science Center, Key Laboratory of Advanced Energy Materials Chemistry (MOE), Institute of New Catalytic Materials Science, School of Materials Science and Engineering, Smart Sensing, Nankai University, Tianjin 300350, China
Tiehong Chen
Interdisciplinary Science Center, Key Laboratory of Advanced Energy Materials Chemistry (MOE), Institute of New Catalytic Materials Science, School of Materials Science and Engineering, Smart Sensing, Nankai University, Tianjin 300350, China
Mesoporous bioactive glass is a promising biomaterial for bone tissue engineering due to its good biocompatibility and bioactivity. In this work, we synthesized a hierarchically porous bioactive glass (HPBG) using polyelectrolyte-surfactant mesomorphous complex as template. Through the interaction with silicate oligomers, calcium and phosphorus sources were successfully introduced into the synthesis of hierarchically porous silica, and HPBG with ordered mesoporous and nanoporous structures was obtained. The morphology, pore structure and particle size of HPBG can be controlled by adding block copolymer as co-template or adjusting the synthesis parameters. The ability to induce hydroxyapatite deposition in simulated body fluids (SBF) demonstrated the good in vitro bioactivity of HPBG. Overall, this work provides a general method for the synthesis of hierarchically porous bioactive glasses.
