Pyroptosis in the Retinal Neurovascular Unit: New Insights Into Diabetic Retinopathy

Chunren Meng; Chunren Meng; Chufeng Gu; Chufeng Gu; Shuai He; Shuai He; Tong Su; Tong Su; Thashi Lhamo; Deji Draga; Qinghua Qiu; Qinghua Qiu; Qinghua Qiu

doi:10.3389/fimmu.2021.763092

Frontiers in Immunology (Oct 2021)

Pyroptosis in the Retinal Neurovascular Unit: New Insights Into Diabetic Retinopathy

Chunren Meng,
Chunren Meng,
Chufeng Gu,
Chufeng Gu,
Shuai He,
Shuai He,
Tong Su,
Tong Su,
Thashi Lhamo,
Deji Draga,
Qinghua Qiu,
Qinghua Qiu,
Qinghua Qiu

Affiliations

Chunren Meng: Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Chunren Meng: National Clinical Research Center for Eye Diseases; Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China
Chufeng Gu: Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Chufeng Gu: National Clinical Research Center for Eye Diseases; Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China
Shuai He: Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shuai He: National Clinical Research Center for Eye Diseases; Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China
Tong Su: Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Tong Su: National Clinical Research Center for Eye Diseases; Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China
Thashi Lhamo: Department of Ophthalmology, Shigatse People’s Hospital, Shigatse, China
Deji Draga: Department of Ophthalmology, Shigatse People’s Hospital, Shigatse, China
Qinghua Qiu: Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Qinghua Qiu: National Clinical Research Center for Eye Diseases; Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China
Qinghua Qiu: Department of Ophthalmology, Shigatse People’s Hospital, Shigatse, China

DOI: https://doi.org/10.3389/fimmu.2021.763092
Journal volume & issue: Vol. 12

Abstract

Read online

Diabetic retinopathy (DR) is prevalent among people with long-term diabetes mellitus (DM) and remains the leading cause of visual impairment in working-aged people. DR is related to chronic low-level inflammatory reactions. Pyroptosis is an emerging type of inflammatory cell death mediated by gasdermin D (GSDMD), NOD-like receptors and inflammatory caspases that promote interleukin-1β (IL-1β) and IL-18 release. In addition, the retinal neurovascular unit (NVU) is the functional basis of the retina. Recent studies have shown that pyroptosis may participate in the destruction of retinal NVU cells in simulated hyperglycemic DR environments. In this review, we will clarify the importance of pyroptosis in the retinal NVU during the development of DR.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

About the journal

Abstract

Keywords