Nature Communications (Jul 2018)

Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70

  • Meng Zhao,
  • Mattias N. D. Svensson,
  • Koen Venken,
  • Ashu Chawla,
  • Shu Liang,
  • Isaac Engel,
  • Piotr Mydel,
  • Jeremy Day,
  • Dirk Elewaut,
  • Nunzio Bottini,
  • Mitchell Kronenberg

DOI
https://doi.org/10.1038/s41467-018-05095-7
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 17

Abstract

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Invariant natural killer T (iNKT) cells can be subsetted based on their cytokine productions. Here the authors show, using Zap70 mutant mice, that interferon-γ secreting (IFN-γ) iNKT cells may be induced by hampered T cell receptor signallings to help ameliorate interleukin-17-mediated joint inflammation.