The Korean Journal of Gastroenterology (Jun 2024)

Effective Endoscopic Submucosal Dissection of a Huge Esophageal Liposarcoma: A Case Report

  • Myeong Jin Lee,
  • Moon Won Lee,
  • Dong Chan Joo,
  • Seung Min Hong,
  • Dong Hoon Baek,
  • Bong Eun Lee,
  • Gwang Ha Kim,
  • Geun Am Song

DOI
https://doi.org/10.4166/kjg.2024.047
Journal volume & issue
Vol. 83, no. 6
pp. 243 – 246

Abstract

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This case report presents the successful endoscopic submucosal dissection (ESD) of a well-differentiated esophageal liposarcoma in a 51-year-old male with persistent dysphagia. The cause was initially diagnosed as a 10 cm pedunculated lesion extending from the upper esophageal sphincter to the mid-esophagus. An ESD was chosen over traditional surgery because it is less invasive. The procedure involved a precise submucosal injection and excision with special techniques to manage bleeding from a central vessel. Despite the extraction challenges owing to the size of the lesion, it was successfully removed orally. A histopathological examination of the 8.3×4.2×2.3 cm specimen revealed the characteristic features of a well-differentiated liposarcoma, including MDM2 and CDK4 positivity. The follow-up revealed no recurrence, and active surveillance has been performed since. This report highlights the versatility of ESD in treating significant esophageal tumors and provides evidence for its efficacy as a minimally invasive alternative.

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