Network Pharmacology-based Research on Lipid Lowering Mechanism of Walnut Cold-press Meal

Abstract

This paper explores the action mechanism of walnut cold-press meal in reducing fat from the perspective of network pharmacology.Active components and potential targets of walnut cold-press meal were obtained through TCMSP database and literature mining.GeneCards and other databases were used to predict and screen Hyperlipidemia (HLP) related genes,while Cytoscape 3.7.2 software was applied to construct a “drug-active component-disease-target” network to the formation of walnuts to prevent HLP components and target interactions,and analysis of GO function and KEGG pathway enrichment.Results show that 14 active components of Walnut cold-press meal were identified,among which 7 components have 59 HLP-related targets.HAS2,NCOA2,ESR1,CAT,AR,VEGFA and POR may be the key targets of HLP,with the main signaling pathways being HIF-1 signaling pathway,TNF signaling pathway,Chagas disease,and malaria signaling pathway.HLP is prevented by multi-component,multi-target and multi-pathway,among which the most targeted components are quercetin,rutin,catechin,erucic acid and ellagic acid.Targets most affected by the compounds are hyaluronate synthase 2,nuclear receptor coactivator factor 2,estrogen receptor,catalase,androgen receptor,vascular endothelial growth factor A and NHLPPH--cytochrome P450 reductase.

Keywords

• walnut cold-press meal
• hyperlipidemia
• network pharmacology
• mechanism