Prevention and early treatment of the long-term physical effects of COVID-19 in adults: design of a randomised controlled trial of resistance exercise—CISCO-21

A. Morrow; Stuart R. Gray; H. K. Bayes; R. Sykes; E. McGarry; D. Anderson; D. Boiskin; C. Burke; J. G. F. Cleland; C. Goodyear; T. Ibbotson; C. C. Lang; McConnachie; F. Mair; K. Mangion; M. Patel; N. Sattar; D. Taggart; R. Taylor; S. Dawkes; C. Berry

doi:10.1186/s13063-022-06632-y

Trials (Aug 2022)

Prevention and early treatment of the long-term physical effects of COVID-19 in adults: design of a randomised controlled trial of resistance exercise—CISCO-21

A. Morrow,
Stuart R. Gray,
H. K. Bayes,
R. Sykes,
E. McGarry,
D. Anderson,
D. Boiskin,
C. Burke,
J. G. F. Cleland,
C. Goodyear,
T. Ibbotson,
C. C. Lang,
McConnachie,
F. Mair,
K. Mangion,
M. Patel,
N. Sattar,
D. Taggart,
R. Taylor,
S. Dawkes,
C. Berry

Affiliations

A. Morrow: Institute of Cardiovascular and Medical Sciences, University of Glasgow
Stuart R. Gray: Institute of Cardiovascular and Medical Sciences, University of Glasgow
H. K. Bayes: Glasgow Royal Infirmary, NHS Greater Glasgow and Clyde
R. Sykes: Institute of Cardiovascular and Medical Sciences, University of Glasgow
E. McGarry: Glasgow Royal Infirmary, NHS Greater Glasgow and Clyde
D. Anderson: Glasgow Royal Infirmary, NHS Greater Glasgow and Clyde
D. Boiskin: Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde
C. Burke: Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde
J. G. F. Cleland: Robertson Centre for Biostatistics, Institute of Health and Wellbeing, University of Glasgow
C. Goodyear: Institute of Inflammation, Infection and Immunity, University of Glasgow
T. Ibbotson: General Practice and Primary Care, Institute of Health and Wellbeing, University of Glasgow
C. C. Lang: School of Medicine, University of Dundee
McConnachie: Robertson Centre for Biostatistics, Institute of Health and Wellbeing, University of Glasgow
F. Mair: General Practice and Primary Care, Institute of Health and Wellbeing, University of Glasgow
K. Mangion: Institute of Cardiovascular and Medical Sciences, University of Glasgow
M. Patel: University Hospital Wishaw, NHS Lanarkshire
N. Sattar: Institute of Cardiovascular and Medical Sciences, University of Glasgow
D. Taggart: NHS Project Management Unit, NHS Greater Glasgow and Clyde
R. Taylor: General Practice and Primary Care, Institute of Health and Wellbeing, University of Glasgow
S. Dawkes: School for Nursing Midwifery and Paramedic Practice, Robert Gordon University
C. Berry: Institute of Cardiovascular and Medical Sciences, University of Glasgow

DOI: https://doi.org/10.1186/s13063-022-06632-y
Journal volume & issue: Vol. 23, no. 1
pp. 1 – 13

Abstract

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Abstract Background Coronavirus disease-19 (COVID-19) infection causes persistent health problems such as breathlessness, chest pain and fatigue, and therapies for the prevention and early treatment of post-COVID-19 syndromes are needed. Accordingly, we are investigating the effect of a resistance exercise intervention on exercise capacity and health status following COVID-19 infection. Methods A two-arm randomised, controlled clinical trial including 220 adults with a diagnosis of COVID-19 in the preceding 6 months. Participants will be classified according to clinical presentation: Group A, not hospitalised due to COVID but persisting symptoms for at least 4 weeks leading to medical review; Group B, discharged after an admission for COVID and with persistent symptoms for at least 4 weeks; or Group C, convalescing in hospital after an admission for COVID. Participants will be randomised to usual care or usual care plus a personalised and pragmatic resistance exercise intervention for 12 weeks. The primary outcome is the incremental shuttle walks test (ISWT) 3 months after randomisation with secondary outcomes including spirometry, grip strength, short performance physical battery (SPPB), frailty status, contacts with healthcare professionals, hospitalisation and questionnaires assessing health-related quality of life, physical activity, fatigue and dyspnoea. Discussion Ethical approval has been granted by the National Health Service (NHS) West of Scotland Research Ethics Committee (REC) (reference: GN20CA537) and recruitment is ongoing. Trial findings will be disseminated through patient and public forums, scientific conferences and journals. Trial registration ClinicialTrials.gov NCT04900961 . Prospectively registered on 25 May 2021

Published in Trials

ISSN: 1745-6215 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Medicine (General)
Website: https://trialsjournal.biomedcentral.com

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