Nature Communications (Sep 2022)

Effects of biological sex mismatch on neural progenitor cell transplantation for spinal cord injury in mice

  • Michael Pitonak,
  • Miriam Aceves,
  • Prakruthi Amar Kumar,
  • Gabrielle Dampf,
  • Peyton Green,
  • Ashley Tucker,
  • Valerie Dietz,
  • Diego Miranda,
  • Sunjay Letchuman,
  • Michelle M. Jonika,
  • David Bautista,
  • Heath Blackmon,
  • Jennifer N. Dulin

DOI
https://doi.org/10.1038/s41467-022-33134-x
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 12

Abstract

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In this study, Pitonak et al. report that transplantation of neural progenitor cells derived from male donors trigger an immune rejection response following transplantation into sites of spinal cord injury in female mice.