Nature Communications (Aug 2019)

Uncovering the biosynthetic potential of rare metagenomic DNA using co-occurrence network analysis of targeted sequences

  • Vincent Libis,
  • Niv Antonovsky,
  • Mengyin Zhang,
  • Zhuo Shang,
  • Daniel Montiel,
  • Jeffrey Maniko,
  • Melinda A. Ternei,
  • Paula Y. Calle,
  • Christophe Lemetre,
  • Jeremy G. Owen,
  • Sean F. Brady

DOI
https://doi.org/10.1038/s41467-019-11658-z
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 9

Abstract

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Soil microorganisms are a rich source of bioactive molecules. Here, the authors present a targeted sequencing workflow that reconstructs the clustered organization of biosynthetic domains in metagenomic libraries from amplicon data, thus guiding the discovery of novel metabolites from rare members of the soil microbiome.