Pivotal Roles of T-Helper 17-Related Cytokines, IL-17, IL-22, and IL-23, in Inflammatory Diseases

Ning Qu; Mingli Xu; Izuru Mizoguchi; Jun-ichi Furusawa; Kotaro Kaneko; Kazunori Watanabe; Junichiro Mizuguchi; Masahiro Itoh; Yutaka Kawakami; Takayuki Yoshimoto

doi:10.1155/2013/968549

Clinical and Developmental Immunology (Jan 2013)

Pivotal Roles of T-Helper 17-Related Cytokines, IL-17, IL-22, and IL-23, in Inflammatory Diseases

Ning Qu,
Mingli Xu,
Izuru Mizoguchi,
Jun-ichi Furusawa,
Kotaro Kaneko,
Kazunori Watanabe,
Junichiro Mizuguchi,
Masahiro Itoh,
Yutaka Kawakami,
Takayuki Yoshimoto

Affiliations

Ning Qu: Department of Anatomy, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, Japan
Mingli Xu: Division of Cellular Signaling, Institute for Advanced Medical Research School of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
Izuru Mizoguchi: Department of Immunoregulation, Institute of Medical Science, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo160-8402, Japan
Jun-ichi Furusawa: Department of Immunoregulation, Institute of Medical Science, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo160-8402, Japan
Kotaro Kaneko: Department of Immunoregulation, Institute of Medical Science, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo160-8402, Japan
Kazunori Watanabe: Department of Immunoregulation, Institute of Medical Science, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo160-8402, Japan
Junichiro Mizuguchi: Department of Immunology, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, Japan
Masahiro Itoh: Department of Anatomy, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, Japan
Yutaka Kawakami: Division of Cellular Signaling, Institute for Advanced Medical Research School of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
Takayuki Yoshimoto: Department of Immunoregulation, Institute of Medical Science, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo160-8402, Japan

DOI: https://doi.org/10.1155/2013/968549
Journal volume & issue: Vol. 2013

Abstract

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T-helper 17 (Th17) cells are characterized by producing interleukin-17 (IL-17, also called IL-17A), IL-17F, IL-21, and IL-22 and potentially TNF-α and IL-6 upon certain stimulation. IL-23, which promotes Th17 cell development, as well as IL-17 and IL-22 produced by the Th17 cells plays essential roles in various inflammatory diseases, such as experimental autoimmune encephalomyelitis, rheumatoid arthritis, colitis, and Concanavalin A-induced hepatitis. In this review, we summarize the characteristics of the functional role of Th17 cells, with particular focus on the Th17 cell-related cytokines such as IL-17, IL-22, and IL-23, in mouse models and human inflammatory diseases.

Published in Clinical and Developmental Immunology

ISSN: 1740-2522 (Print); 1740-2530 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: https://onlinelibrary.wiley.com/journal/1607

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