Visual evoked potentials in diagnostics of optic neuropathy associated with renal failure

Postępy Higieny i Medycyny Doświadczalnej. 2017;71(1):32-39 DOI 10.5604/01.3001.0010.3787

 

Journal Homepage

Journal Title: Postępy Higieny i Medycyny Doświadczalnej

ISSN: 0032-5449 (Print); 1732-2693 (Online)

Publisher: Index Copernicus International S.A.

Society/Institution: Institute of Immunology and Experimental Therapy

LCC Subject Category: Medicine

Country of publisher: Poland

Language of fulltext: English, Polish

Full-text formats available: PDF

 

AUTHORS

Małgorzata Jurys (Uniwersyteckie Centrum Okulistyki i Onkologii Samodzielnego Publicznego Szpitala Klinicznego Śląskiego Uniwersytetu Medycznego w Katowicach)
Sebastian Sirek (Uniwersyteckie Centrum Okulistyki i Onkologii Samodzielnego Publicznego Szpitala Klinicznego Śląskiego Uniwersytetu Medycznego w Katowicach)
Aureliusz Kolonko (Katedra i Klinika Nefrologii, Transplantologii i Chorób Wewnętrznych, Wydział Lekarski w Katowicach)
Dorota Pojda-Wilczek (Uniwersyteckie Centrum Okulistyki i Onkologii Samodzielnego Publicznego Szpitala Klinicznego Śląskiego Uniwersytetu Medycznego w Katowicach)

EDITORIAL INFORMATION

Double blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 8 weeks

 

Abstract | Full Text | Full Text

Chronic renal failure is associated with many neurological complications. Due to accumulation of uremic neurotoxins axonal degeneration with its secondary demyelination occurs, which results in development of polineuropathy in 60-100% of patients with chronic renal failure. One of the most severe peripheral neuropathy is optic neuropathy. It is associated with visual deterioration and reduction in quality of life. Symptoms of the optic neuropathy may appear either before or after dialysis therapy. They often worsen after renal transplant, probably due to immunosuppressive regimen. Early diagnostics of the optic neuropathy became possible by using visual evoked potentials (VEP). This reliable, sensitive and noninvasive technique provides a direct measure of subclinical impairment of visual pathways. Among hemodialysed or immunosupressed patients one can observe abnormal VEP parameters – especially prolonged latency of the P100 component, less often fluctuation of its amplitude. These alterations are pronounced even if clinical examination reveals no abnormalities. This review presents a summary of current use of visual evoked potentials in monitoring of patients with chronic renal failure.