Myelofibrosis secondary to Hodgkin's lymphoma: A case report

Abstract

A 23-year-old male was misdiagnosed as a case of tubercular lymphadenitis based on fever with B-symptoms and finding of epithelioid granuloma on fine-needle aspiration of mesenteric lymph node and was started on antitubercular treatment from an outside hospital. Since the patient had progression of symptoms, we re-evaluated the case. Contrast-enhanced computed tomography showed multiple conglomerated necrotic cervical, peritoneal lymph nodes, hepatosplenomegaly, and multiple mixed sclerotic lytic lesions in multiple vertebral bodies and pelvis. An excision lymph node biopsy was suggestive of a nodular sclerosis variant of Hodgkin's lymphoma. A bone marrow study was performed subsequent to new-onset bicytopenia. Bone marrow aspiration was dry and bone marrow biopsy showed myelofibrosis. Thus, a diagnosis of myelofibrosis secondary to Hodgkin's lymphoma was made.

Keywords

• b-symptoms
• generalized lymphadenopathy
• hodgkin's lymphoma
• myelofibrosis