Biocompatible Chitosan Oligosaccharide Modified Gold Nanorods as Highly Effective Photothermal Agents for Ablation of Breast Cancer Cells
Panchanathan Manivasagan,
Subramaniyan Bharathiraja,
Madhappan Santha Moorthy,
Sudip Mondal,
Thanh Phuoc Nguyen,
Hyehyun Kim,
Thi Tuong Vy Phan,
Kang Dae Lee,
Junghwan Oh
Affiliations
Panchanathan Manivasagan
Marine-Integrated Bionics Research Center, Pukyong National University, Busan 48513, Korea
Subramaniyan Bharathiraja
Marine-Integrated Bionics Research Center, Pukyong National University, Busan 48513, Korea
Madhappan Santha Moorthy
Marine-Integrated Bionics Research Center, Pukyong National University, Busan 48513, Korea
Sudip Mondal
Marine-Integrated Bionics Research Center, Pukyong National University, Busan 48513, Korea
Thanh Phuoc Nguyen
Department of Biomedical Engineering and Center for Marine-Integrated Biotechnology (BK21 Plus), Pukyong National University, Busan 48513, Korea
Hyehyun Kim
Marine-Integrated Bionics Research Center, Pukyong National University, Busan 48513, Korea
Thi Tuong Vy Phan
Marine-Integrated Bionics Research Center, Pukyong National University, Busan 48513, Korea
Kang Dae Lee
Department of Otolaryngology—Head and Neck Surgery, Kosin University Gospel Hospital, Kosin University College of Medicine, 262 Gamcheon-ro, Seo-Gu, Busan 602-702, Korea
Junghwan Oh
Marine-Integrated Bionics Research Center, Pukyong National University, Busan 48513, Korea
Photothermal therapy (PTT) using biocompatible nanomaterials have recently attracted much attention as a novel candidate technique for cancer therapy. In this work we report the performance of newly synthesized multidentate chitosan oligosaccharide modified gold nanorods (AuNRs-LA-COS) as novel agents for PTT of cancer cells due to their excellent biocompatibility, photothermal stability, and high absorption in the near-infrared (NIR) region. The AuNRs-LA-COS exhibit a strong NIR absorption peak at 838 nm with a mean length of 26 ± 3.1 nm and diameter of 6.8 ± 1.7 nm, respectively. The temperature of AuNRs-LA-COS rapidly reached 52.6 °C for 5 min of NIR laser irradiation at 2 W/cm2. The AuNRs-LA-COS had very low cytotoxicity and exhibited high efficiency for the ablation of breast cancer cells in vitro. The tumor-bearing mice were completely ablated without tumor recurrence after photothermal treatment with AuNRs-LA-COS (25 µg/mL) under laser irradiation. In summary, this study demonstrated that AuNRs-LA-COS with laser irradiation as novel agents pave an alternative way for breast cancer therapy and hold great promise for clinical trials in the near future.
