Clinical application of platelet-rich fibrin to enhance dental implant stability: A systematic review and meta-analysis
Shuai Guan,
Tiepeng Xiao,
Jiuping Bai,
Chunliu Ning,
Xingkui Zhang,
Lei Yang,
Xiangjun Li
Affiliations
Shuai Guan
Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Hebei Medical University and Hebei Key Laboratory of Stomatology, Shijiazhuang, 050017, PR China
Tiepeng Xiao
The Second Affiliated Hospital of Hebei Medical University, Shijiazhuang, 050000, PR China
Jiuping Bai
Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Hebei Medical University and Hebei Key Laboratory of Stomatology, Shijiazhuang, 050017, PR China
Chunliu Ning
Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Hebei Medical University and Hebei Key Laboratory of Stomatology, Shijiazhuang, 050017, PR China
Xingkui Zhang
Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Hebei Medical University and Hebei Key Laboratory of Stomatology, Shijiazhuang, 050017, PR China
Lei Yang
Department of Epidemiology and Statistics, School of Public Health, Hebei Key Laboratory of Environment and Human Health, Hebei Medical University, Shijiazhuang, 050017, PR China
Xiangjun Li
Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Hebei Medical University and Hebei Key Laboratory of Stomatology, Shijiazhuang, 050017, PR China; Corresponding author.
Objective: To investigate the effect of platelet-rich fibrin application on implant stability. Study design: Five databases, namely, PubMed, Embase, Web of Science, Wiley, and China National Knowledge Infrastructure, were searched for reports published up to November 20, 2022. Randomized controlled trials (RCT), including parallel RCTs and split-mouth RCTs, with at least 10 patients/sites were considered for inclusion. Results: After screening based on the inclusion criteria, ten RCTs were included. Low heterogeneity was observed in study characteristics, outcome variables, and estimation scales (I2 = 27.2%, P = 0.19). The qualitative and meta-analysis results showed that PRF increased the effect of implant stabilizers after implant surgery. Conclusions: The results of the present systematic review and meta-analysis suggest that PRF can increase implant stability after implant surgery. PRF may also have a role in accelerating bone healing and tends to promote new bone formation at the implant site.