Wolf′s isotopic response: Report of a case and review of literature

Abstract

"Wolf′s isotopic response" refers to the occurrence of a new dermatosis at the site of previously healed dermatosis. A number of factors including viral, neural, vascular, and immunologic factors have been implicated in the causation of this peculiar response but none has been proven conclusively. Here, we report a case where lichen planus developed at the site of dermatofibrosarcoma protruberans that had been previously treated with surgery and radiotherapy. We also put forth a hypothesis on the genesis of isotopic response considering the above mentioned factors.

Keywords

• Immune response
• isotopic response
• dermatofibrosarcoma protuberans
• lichen planus