Nature Communications (Mar 2022)
Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci
- Xianyong Yin,
- Lap Sum Chan,
- Debraj Bose,
- Anne U. Jackson,
- Peter VandeHaar,
- Adam E. Locke,
- Christian Fuchsberger,
- Heather M. Stringham,
- Ryan Welch,
- Ketian Yu,
- Lilian Fernandes Silva,
- Susan K. Service,
- Daiwei Zhang,
- Emily C. Hector,
- Erica Young,
- Liron Ganel,
- Indraniel Das,
- Haley Abel,
- Michael R. Erdos,
- Lori L. Bonnycastle,
- Johanna Kuusisto,
- Nathan O. Stitziel,
- Ira M. Hall,
- Gregory R. Wagner,
- FinnGen,
- Jian Kang,
- Jean Morrison,
- Charles F. Burant,
- Francis S. Collins,
- Samuli Ripatti,
- Aarno Palotie,
- Nelson B. Freimer,
- Karen L. Mohlke,
- Laura J. Scott,
- Xiaoquan Wen,
- Eric B. Fauman,
- Markku Laakso,
- Michael Boehnke
Affiliations
- Xianyong Yin
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health
- Lap Sum Chan
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health
- Debraj Bose
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health
- Anne U. Jackson
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health
- Peter VandeHaar
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health
- Adam E. Locke
- McDonnell Genome Institute, Washington University School of Medicine
- Christian Fuchsberger
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health
- Heather M. Stringham
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health
- Ryan Welch
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health
- Ketian Yu
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health
- Lilian Fernandes Silva
- Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland
- Susan K. Service
- Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles
- Daiwei Zhang
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health
- Emily C. Hector
- Department of Statistics, North Carolina State University
- Erica Young
- McDonnell Genome Institute, Washington University School of Medicine
- Liron Ganel
- McDonnell Genome Institute, Washington University School of Medicine
- Indraniel Das
- McDonnell Genome Institute, Washington University School of Medicine
- Haley Abel
- Department of Medicine, Washington University School of Medicine
- Michael R. Erdos
- Molecular Genetics Section, Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health
- Lori L. Bonnycastle
- Molecular Genetics Section, Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health
- Johanna Kuusisto
- Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland
- Nathan O. Stitziel
- McDonnell Genome Institute, Washington University School of Medicine
- Ira M. Hall
- Center for Genomic Health, Department of Genetics, Yale University
- Gregory R. Wagner
- Metabolon, Inc.
- FinnGen
- Jian Kang
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health
- Jean Morrison
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health
- Charles F. Burant
- Department of Internal Medicine, University of Michigan
- Francis S. Collins
- Molecular Genetics Section, Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health
- Samuli Ripatti
- Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki
- Aarno Palotie
- Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki
- Nelson B. Freimer
- Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles
- Karen L. Mohlke
- Department of Genetics, University of North Carolina at Chapel Hill
- Laura J. Scott
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health
- Xiaoquan Wen
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health
- Eric B. Fauman
- Internal Medicine Research Unit, Pfizer Worldwide Research, Development and Medical
- Markku Laakso
- Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland
- Michael Boehnke
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health
- DOI
- https://doi.org/10.1038/s41467-022-29143-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
The Finnish population is enriched for genetic variants which are rare in other populations. Here, the authors find new genetic loci associated with 1391 circulating metabolites in 6136 Finnish men, demonstrating that metabolite genetic associations can help elucidate disease mechanisms.
