The interaction between endogenous GABA, functional connectivity, and behavioral flexibility is critically altered with advanced age

Kirstin-Friederike Heise; Laura Rueda-Delgado; Sima Chalavi; Bradley R. King; Thiago Santos Monteiro; Richard A. E. Edden; Dante Mantini; Stephan P. Swinnen

doi:10.1038/s42003-022-03378-w

Communications Biology (May 2022)

The interaction between endogenous GABA, functional connectivity, and behavioral flexibility is critically altered with advanced age

Kirstin-Friederike Heise,
Laura Rueda-Delgado,
Sima Chalavi,
Bradley R. King,
Thiago Santos Monteiro,
Richard A. E. Edden,
Dante Mantini,
Stephan P. Swinnen

Affiliations

Kirstin-Friederike Heise: Department of Movement Sciences, Movement Control and Neuroplasticity Research Group, KU Leuven
Laura Rueda-Delgado: Department of Movement Sciences, Movement Control and Neuroplasticity Research Group, KU Leuven
Sima Chalavi: Department of Movement Sciences, Movement Control and Neuroplasticity Research Group, KU Leuven
Bradley R. King: Department of Movement Sciences, Movement Control and Neuroplasticity Research Group, KU Leuven
Thiago Santos Monteiro: Department of Movement Sciences, Movement Control and Neuroplasticity Research Group, KU Leuven
Richard A. E. Edden: The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine
Dante Mantini: Department of Movement Sciences, Movement Control and Neuroplasticity Research Group, KU Leuven
Stephan P. Swinnen: Department of Movement Sciences, Movement Control and Neuroplasticity Research Group, KU Leuven

DOI: https://doi.org/10.1038/s42003-022-03378-w
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 17

Abstract

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An integrated analysis of GABA concentration, interhemispheric phase-based connectivity behavior and in healthy human participants revealed a task-specific association between GABA concentration and motor-cortical connectivity. These results shed light on how GABA is involved in neural oscillations and behavioral performance.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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