The acetyllysine reader BRD3R promotes human nuclear reprogramming and regulates mitosis

Zhicheng Shao; Ruowen Zhang; Alireza Khodadadi-Jamayran; Bo Chen; Michael R. Crowley; Muhamad A. Festok; David K. Crossman; Tim M. Townes; Kejin Hu

doi:10.1038/ncomms10869

Nature Communications (Mar 2016)

The acetyllysine reader BRD3R promotes human nuclear reprogramming and regulates mitosis

Zhicheng Shao,
Ruowen Zhang,
Alireza Khodadadi-Jamayran,
Bo Chen,
Michael R. Crowley,
Muhamad A. Festok,
David K. Crossman,
Tim M. Townes,
Kejin Hu

Affiliations

Zhicheng Shao: Department of Biochemistry and Molecular Genetics, Stem Cell Institute, University of Alabama at Birmingham
Ruowen Zhang: Department of Biochemistry and Molecular Genetics, Stem Cell Institute, University of Alabama at Birmingham
Alireza Khodadadi-Jamayran: Department of Biochemistry and Molecular Genetics, Stem Cell Institute, University of Alabama at Birmingham
Bo Chen: Department of Biochemistry and Molecular Genetics, Stem Cell Institute, University of Alabama at Birmingham
Michael R. Crowley: Department of Genetics, Howell and Elizabeth Heflin Center for Genomic Science, University of Alabama at Birmingham
Muhamad A. Festok: Department of Biochemistry and Molecular Genetics, Stem Cell Institute, University of Alabama at Birmingham
David K. Crossman: Department of Genetics, Howell and Elizabeth Heflin Center for Genomic Science, University of Alabama at Birmingham
Tim M. Townes: Department of Biochemistry and Molecular Genetics, Stem Cell Institute, University of Alabama at Birmingham
Kejin Hu: Department of Biochemistry and Molecular Genetics, Stem Cell Institute, University of Alabama at Birmingham

DOI: https://doi.org/10.1038/ncomms10869
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 15

Abstract

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The reprogramming of fibroblasts to pluripotent stem cells has been well documented but there is interest in identifying additional factors involved. Here, the authors perform a screen of human kinases and show that the bromodomain protein, BRD3R, can promote reprogramming and suggest a role for this factor in regulating mitosis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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