Prefrontal projections to the thalamic nucleus reuniens mediate fear extinction

Karthik R. Ramanathan; Jingji Jin; Thomas F. Giustino; Martin R. Payne; Stephen Maren

doi:10.1038/s41467-018-06970-z

Nature Communications (Oct 2018)

Prefrontal projections to the thalamic nucleus reuniens mediate fear extinction

Karthik R. Ramanathan,
Jingji Jin,
Thomas F. Giustino,
Martin R. Payne,
Stephen Maren

Affiliations

Karthik R. Ramanathan: Department of Psychological and Brain Sciences and Institute for Neuroscience, Texas A&M University
Jingji Jin: Department of Psychological and Brain Sciences and Institute for Neuroscience, Texas A&M University
Thomas F. Giustino: Department of Psychological and Brain Sciences and Institute for Neuroscience, Texas A&M University
Martin R. Payne: Department of Psychological and Brain Sciences and Institute for Neuroscience, Texas A&M University
Stephen Maren: Department of Psychological and Brain Sciences and Institute for Neuroscience, Texas A&M University

DOI: https://doi.org/10.1038/s41467-018-06970-z
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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Previous work has shown that the thalamic nucleus reuniens (RE) is involved in memory and emotion. Here the authors report that the RE and its inputs from the medial prefrontal cortex are indispensable for the top-down inhibition of fear memories after extinction.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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