Nature Communications (Jan 2021)
Endophilin A2 deficiency protects rodents from autoimmune arthritis by modulating T cell activation
- Ulrika Norin,
- Carola Rintisch,
- Liesu Meng,
- Florian Forster,
- Diana Ekman,
- Jonatan Tuncel,
- Katrin Klocke,
- Johan Bäcklund,
- Min Yang,
- Michael Y. Bonner,
- Gonzalo Fernandez Lahore,
- Jaime James,
- Klementy Shchetynsky,
- Maria Bergquist,
- Inger Gjertsson,
- Norbert Hubner,
- Liselotte Bäckdahl,
- Rikard Holmdahl
Affiliations
- Ulrika Norin
- Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute
- Carola Rintisch
- Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute
- Liesu Meng
- Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute
- Florian Forster
- Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute
- Diana Ekman
- Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute
- Jonatan Tuncel
- Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute
- Katrin Klocke
- Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute
- Johan Bäcklund
- Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute
- Min Yang
- Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute
- Michael Y. Bonner
- Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute
- Gonzalo Fernandez Lahore
- Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute
- Jaime James
- Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute
- Klementy Shchetynsky
- Rheumatology Unit, Department of Medicine, Karolinska Institute and Karolinska University Hospital
- Maria Bergquist
- Department of Rheumatology and Inflammation Research, Institute for Medicine, Sahlgrenska Academy, University of Gothenburg
- Inger Gjertsson
- Department of Rheumatology and Inflammation Research, Institute for Medicine, Sahlgrenska Academy, University of Gothenburg
- Norbert Hubner
- Cardiovascular and Metabolic Sciences, Max-Delbrück-Center for Molecular Medicine (MDC)
- Liselotte Bäckdahl
- Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute
- Rikard Holmdahl
- Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute
- DOI
- https://doi.org/10.1038/s41467-020-20586-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
The autoimmune disorder, rheumatoid arthritis (RA), has been associated with multiple pathophysiological factors. Here the authors show that deficiency in endophilin A2 in rodents protects them from experimental arthritis by altering T cell activation threshold and effector functions, thereby hinting a potential target for RA therapy.
