Aβ(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage

Sonia Ciudad; Eduard Puig; Thomas Botzanowski; Moeen Meigooni; Andres S. Arango; Jimmy Do; Maxim Mayzel; Mariam Bayoumi; Stéphane Chaignepain; Giovanni Maglia; Sarah Cianferani; Vladislav Orekhov; Emad Tajkhorshid; Benjamin Bardiaux; Natàlia Carulla

doi:10.1038/s41467-020-16566-1

Nature Communications (Jun 2020)

Aβ(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage

Sonia Ciudad,
Eduard Puig,
Thomas Botzanowski,
Moeen Meigooni,
Andres S. Arango,
Jimmy Do,
Maxim Mayzel,
Mariam Bayoumi,
Stéphane Chaignepain,
Giovanni Maglia,
Sarah Cianferani,
Vladislav Orekhov,
Emad Tajkhorshid,
Benjamin Bardiaux,
Natàlia Carulla

Affiliations

Sonia Ciudad: University of Bordeaux, CBMN (UMR 5248)—CNRS—IPB, Institut Européen de Chimie et Biologie
Eduard Puig: University of Bordeaux, CBMN (UMR 5248)—CNRS—IPB, Institut Européen de Chimie et Biologie
Thomas Botzanowski: Laboratoire de Spectrométrie de Masse BioOrganique, Université de Strasbourg, CNRS UMR7178, IPHC
Moeen Meigooni: NIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, Center for Biophysics and Quantitative Biology and Department of Biochemistry, University of Illinois at Urbana-Champaign
Andres S. Arango: NIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, Center for Biophysics and Quantitative Biology and Department of Biochemistry, University of Illinois at Urbana-Champaign
Jimmy Do: NIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, Center for Biophysics and Quantitative Biology and Department of Biochemistry, University of Illinois at Urbana-Champaign
Maxim Mayzel: Swedish NMR Centre, University of Gothenburg
Mariam Bayoumi: Biochemistry, Molecular and Structural Biology Section, University of Leuven
Stéphane Chaignepain: University of Bordeaux, CBMN (UMR 5248)—CNRS—IPB, Institut Européen de Chimie et Biologie
Giovanni Maglia: Groningen Biomolecular Sciences & Biotechnology Institute, University of Groningen
Sarah Cianferani: Laboratoire de Spectrométrie de Masse BioOrganique, Université de Strasbourg, CNRS UMR7178, IPHC
Vladislav Orekhov: Swedish NMR Centre, University of Gothenburg
Emad Tajkhorshid: NIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, Center for Biophysics and Quantitative Biology and Department of Biochemistry, University of Illinois at Urbana-Champaign
Benjamin Bardiaux: Structural Bioinformatics Unit, Department of Structural Biology and Chemistry, C3BI, Institut Pasteur; CNRS UMR3528; CNRS USR3756
Natàlia Carulla: University of Bordeaux, CBMN (UMR 5248)—CNRS—IPB, Institut Européen de Chimie et Biologie

DOI: https://doi.org/10.1038/s41467-020-16566-1
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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Formation of amyloid-beta (Aβ) oligomer pores in the membrane of neurons has been proposed to explain neurotoxicity in Alzheimer´s disease. Here authors present the 3D- structure of an Aβ oligomer formed in a membrane mimicking environment and observe that Aβ tetramers and octamers inserted into lipid bilayers as well-defined pores.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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