Copper-Catalyzed Difluoroalkylation Reaction

Abstract

This review describes recent advances in copper-catalyzed difluoroalkylation reactions. The RCF2 radical is generally proposed in the mechanism of these reactions. At present, various types of copper-catalyzed difluoroalkylation reactions have been realized. According to their characteristics, we classify these difluoroalkylation reactions into three types.

Keywords

• difluoroalkylation
• copper
• radical
• cyclization
• multicomponent
• coupling reaction