Molecules
(Dec 2022)
Copper-Catalyzed Difluoroalkylation Reaction
Dao-Qing Dong,
Shao-Hui Yang,
Pei Wu,
Jin-Zhi Wang,
Ling-Hao Min,
Hao Yang,
Meng-Yu Zhou,
Ze-Hui Wei,
Cai-Zhen Ding,
Yan-Li Wang,
Jia-Hui Gao,
Shu-Jie Wang,
Zu-Li Wang
Affiliations
Dao-Qing Dong
College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, China
Shao-Hui Yang
College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, China
Pei Wu
Shandong Academy of Pesticide Sciences, Beiyuan Street, Jinan 250033, China
Jin-Zhi Wang
Tancheng County Agricultural Technology Popularization Center, Linyi 276100, China
Ling-Hao Min
Qingdao Zhongda Agritech Co., Ltd., Qingdao 266109, China
Hao Yang
College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, China
Meng-Yu Zhou
College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, China
Ze-Hui Wei
College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, China
Cai-Zhen Ding
College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, China
Yan-Li Wang
College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, China
Jia-Hui Gao
College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, China
Shu-Jie Wang
College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, China
Zu-Li Wang
College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, China
DOI
https://doi.org/10.3390/molecules27238461
Journal volume & issue
Vol. 27,
no. 23
Abstract
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This review describes recent advances in copper-catalyzed difluoroalkylation reactions. The RCF2 radical is generally proposed in the mechanism of these reactions. At present, various types of copper-catalyzed difluoroalkylation reactions have been realized. According to their characteristics, we classify these difluoroalkylation reactions into three types.
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