State of Motor-Evacuation Function of the Stomach According to 13C-Octanoate Breath Test in Patients with Gastroesophageal Reflux Disease

Abstract

We examined 58 patients with erosive form of gastroesophageal reflux disease and 10 healthy volunteers. All patients underwent fibrogastroduodenoscopy, 24 hour pH monitoring in the lower third of esophagus, 13C-octanoate breath test, identified concentration of cholecystokinin-pankreozymin in blood serum. It is found that 44.83 % of patients with gastroesophageal reflux disease have delayed, 36.21 % — rapid and 18.97 % — normal motor-e­vacuation function of the stomach. In patients with delayed gastric motility we observed prevalence of bile reflux with pH over 6 in the lower third of the esophagus, amounting to 42 % (p = 0.044), and increased concentration in the blood of cholecystokinin-pankreozymin up to (7.12 ± 0.21) ng/ml (p < 0.05), in healthy subjects — (5.91 ± 0.34) ng/ml. In patients with accelerated motility number of refluxes under 4 was 45 %, and cholecystokinin-pankreozymin le­vel — (4.4 ± 1.2) ng/ml. These data support the view of other authors that causes of heartburn as a leading symptom of gastroesophageal reflux disease can be duodenogastric reflux and visceral hyperalgesia.

Keywords

• gastroesophageal reflux disease
• 13C-octanoate breath test
• cholecystokinin-pankreozymin
• motor-evacuation function of the stomach