Journal of Fungi (May 2024)

Antifungal Activity of Menisporopsin A against Relevant Plant Pathogens

  • Candelario Rodriguez,
  • Masiel Barrios-Jaén,
  • Luis C. Mejía,
  • Marcelino Gutiérrez

DOI
https://doi.org/10.3390/jof10060381
Journal volume & issue
Vol. 10, no. 6
p. 381

Abstract

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Current agrochemicals used in crop farming mainly consist of synthetic compounds with harmful effects on the environment and human health. Crop-associated fungal endophytes, which play many ecological roles including defense against pathogens, represent a promising source for bioactive and ecologically safer molecules in agrochemical discovery. The methanolic extract of the endophyte Menisporopsis sp. LCM 1078 was evaluated in vitro against the plant pathogens Boeremia exigua, Calonectria variabilis, Colletotrichum theobromicola, Colletotrichum tropicale, and Mycena cytricolor. Bioassay-guided isolation using chromatographic techniques followed by detailed chemical characterization by NMR and mass spectrometry led to the identification of menisporopsin A, which showed inhibitory activity in a dose-dependent manner against the five fungal pathogens including an endophytic strain (Colletotrichum tropicale), with MIC values in the range of 0.63–10.0 μg/mL showing a potency equivalent to the broadly employed agrochemical mancozeb.

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