Ambient Particulate Matter Induces In Vitro Toxicity to Intestinal Epithelial Cells without Exacerbating Acute Colitis Induced by Dextran Sodium Sulfate or 2,4,6-Trinitrobenzenesulfonic Acid

Candace Chang; Allen Louie; Yi Zhou; Rajat Gupta; Fengting Liang; Georgina Xanthou; Jason Ereso; Carolina Koletic; Julianne Ching Yang; Farzaneh Sedighian; Venu Lagishetty; Nerea Arias-Jayo; Abdulmalik Altuwayjiri; Ramin Tohidi; Mohamad Navab; Srinivasa Tadiparthi Reddy; Constantinos Sioutas; Tzung Hsiai; Jesus A. Araujo; Jonathan P. Jacobs

doi:10.3390/ijms25137184

International Journal of Molecular Sciences (Jun 2024)

Ambient Particulate Matter Induces In Vitro Toxicity to Intestinal Epithelial Cells without Exacerbating Acute Colitis Induced by Dextran Sodium Sulfate or 2,4,6-Trinitrobenzenesulfonic Acid

Candace Chang,
Allen Louie,
Yi Zhou,
Rajat Gupta,
Fengting Liang,
Georgina Xanthou,
Jason Ereso,
Carolina Koletic,
Julianne Ching Yang,
Farzaneh Sedighian,
Venu Lagishetty,
Nerea Arias-Jayo,
Abdulmalik Altuwayjiri,
Ramin Tohidi,
Mohamad Navab,
Srinivasa Tadiparthi Reddy,
Constantinos Sioutas,
Tzung Hsiai,
Jesus A. Araujo,
Jonathan P. Jacobs

Affiliations

Candace Chang: Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Allen Louie: Division of Cardiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Yi Zhou: Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Rajat Gupta: Division of Cardiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Fengting Liang: Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Georgina Xanthou: Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Jason Ereso: Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Carolina Koletic: Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Julianne Ching Yang: Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Farzaneh Sedighian: Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Venu Lagishetty: Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Nerea Arias-Jayo: Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Abdulmalik Altuwayjiri: USC Viterbi School of Engineering, University of Southern California, Los Angeles, CA 90089, USA
Ramin Tohidi: USC Viterbi School of Engineering, University of Southern California, Los Angeles, CA 90089, USA
Mohamad Navab: Division of Cardiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Srinivasa Tadiparthi Reddy: Division of Cardiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Constantinos Sioutas: USC Viterbi School of Engineering, University of Southern California, Los Angeles, CA 90089, USA
Tzung Hsiai: Division of Cardiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Jesus A. Araujo: Division of Cardiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Jonathan P. Jacobs: Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA

DOI: https://doi.org/10.3390/ijms25137184
Journal volume & issue: Vol. 25, no. 13
p. 7184

Abstract

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Inflammatory bowel disease (IBD) is an immunologically complex disorder involving genetic, microbial, and environmental risk factors. Its global burden has continued to rise since industrialization, with epidemiological studies suggesting that ambient particulate matter (PM) in air pollution could be a contributing factor. Prior animal studies have shown that oral PM10 exposure promotes intestinal inflammation in a genetic IBD model and that PM2.5 inhalation exposure can increase intestinal levels of pro-inflammatory cytokines. PM10 and PM2.5 include ultrafine particles (UFP), which have an aerodynamic diameter of 3, 6 h/day, 3–5 days/week, starting 7–10 days before disease induction. No differences in weight change, clinical disease activity, or histology were observed between the PM and FA-exposed groups. In conclusion, UFP inhalation exposure did not exacerbate intestinal inflammation in acute, chemically-induced colitis models.

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

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