Frontiers in Neuroscience (Nov 2024)
Abnormal topological organization of functional brain networks in the patients with anterior segment ischemic optic neuropathy
Abstract
ObjectiveAn increasing amount of neuroimaging evidence indicates that patients with anterior segment ischemic optic neuropathy (AION) exhibit abnormal brain function and structural architecture. Some studies have shown that there are abnormal functional and structural changes in the brain visual area of AION patients. Nevertheless, the alterations in the topological properties of brain functional connectivity among patients with AION remain unclear. This study aimed to investigate the topological organization of brain functional connectivity in a group of AION patients using graph theory methods.MethodsResting-state magnetic resonance imaging was conducted on 30 AION patients and 24 healthy controls (HCs) matched for age, gender, and education level. For each participant, a high-resolution brain functional network was constructed using time series correlation and quantified through graph theory analysis.ResultsBoth the AION and HC groups presented high-efficiency small-world networks in their brain functional networks. In comparison to the HCs, the AION group exhibited notable reductions in clustering coefficient (Cp) and local efficiency (Eloc). Specifically, significant decreases in Nodal local efficiency were observed in the right Amygdala of the AION group. Moreover, the NBS method detected a significantly modified network (15 nodes, 15 connections) in the AION group compared to the HCs (p < 0.05).ConclusionPatients with AION exhibited topological abnormalities in the human brain connectivity group. Particularly, there was a decrease in Cp and Eloc in the AION group compared to the HC group. The anomalous node centers and functional connections in AION patients were predominantly situated in the prefrontal lobe, temporal lobe, and parietal lobe. These discoveries offer valuable perspectives into the neural mechanisms associated with visual loss, disrupted emotion regulation, and cognitive impairments in individuals with AION.
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