EVALUATION OF THE FREQUENCY OF ARTERIAL AND VENOUS THROMBOSIS AND PREDISPOSING FACTORS IN PATIENTS USING ELTROMBOPAG

Abstract

Objective: Eltrombopag is a small molecule thrombopoietin-receptor agonist used orally for the treatment.There is a high risk of thrombosis associated with the use of Eltrombopag. Our aim in this study is evaluating the incidence of arterial and venous thrombosis in patients using Eltrombopag and followed up in our center with the diagnosis of ITP, MDS and aplastic anemia, and contributing to the literature with the data of Central Black Sea by retrospectively evaluating the predisposing factors. Methodology: In this study, the data of 144 patients who were treated with Eltrombopag with the diagnosis of ITP, MDS and aplastic anemia at Ondokuz Mayıs University Faculty of Medicine Hematology Clinic between 2009-2019 were analyzed retrospectively. The data of the patients were obtained retrospectively from the hospital management information system. Results: The study included 144 patients who treated with Eltrombopag. 66 (45.8%) of the patients were male and 78 (54.2%) were female. The mean age of the patients was 54.12 ± 20.08 years. 102 (70.8%) of the patient were diagnosed with ITP, 31 (21.5%) with aplastic anemia and 12 (7.6%) with MDS. Thrombosis was observed in 7 (4.9%) of 144 patients who treated with Eltrombopag. Venous thrombosis was found in 6 (4.2%) of these patients and arterial thrombosis was found in one patient (0.7%). Conclusion: Eltrombopag treatment poses a risk for thromboembolic events. The treatment process should be followed closely especially in patients with known risk factors for thrombosis.