Regulation of antitumour CD8 T-cell immunity and checkpoint blockade immunotherapy by Neuropilin-1

Abstract

Neuropilin-1 (Nrp-1) is a marker for CD4 + regulatory T cells. Here the authors show that Nrp-1 is co-expressed with PD-1 on a subset of CD8 tumour-infiltrating T lymphocytes and inhibits T-cell migration and cytotoxicity when bound by its ligand semaphorin-3A, while blockade of Nrp-1 synergises with anti-PD-1 to promote antitumour immunity in mouse tumour models.