Lymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions

Maria Gutierrez-Arcelus; Nikola Teslovich; Alex R. Mola; Rafael B. Polidoro; Aparna Nathan; Hyun Kim; Susan Hannes; Kamil Slowikowski; Gerald F. M. Watts; Ilya Korsunsky; Michael B. Brenner; Soumya Raychaudhuri; Patrick J. Brennan

doi:10.1038/s41467-019-08604-4

Nature Communications (Feb 2019)

Lymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions

Maria Gutierrez-Arcelus,
Nikola Teslovich,
Alex R. Mola,
Rafael B. Polidoro,
Aparna Nathan,
Hyun Kim,
Susan Hannes,
Kamil Slowikowski,
Gerald F. M. Watts,
Ilya Korsunsky,
Michael B. Brenner,
Soumya Raychaudhuri,
Patrick J. Brennan

Affiliations

Maria Gutierrez-Arcelus: Department of Medicine, Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School
Nikola Teslovich: Department of Medicine, Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School
Alex R. Mola: Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School
Rafael B. Polidoro: Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School
Aparna Nathan: Department of Medicine, Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School
Hyun Kim: Department of Medicine, Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School
Susan Hannes: Department of Medicine, Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School
Kamil Slowikowski: Department of Medicine, Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School
Gerald F. M. Watts: Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School
Ilya Korsunsky: Department of Medicine, Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School
Michael B. Brenner: Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School
Soumya Raychaudhuri: Department of Medicine, Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School
Patrick J. Brennan: Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-019-08604-4
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

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Innate T cells (ITC) contain many subsets and are poised to promptly respond to antigens and pathogens, but how this poised state is maintained is still unclear. Here the authors perform single-cell RNA-seq to align the various ITC subsets along an ‘innateness gradient’ that is associated with changes in proliferation and effector functions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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