Nature Communications (Jul 2018)

Widespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins

  • Alexander P. Hynes,
  • Geneviève M. Rousseau,
  • Daniel Agudelo,
  • Adeline Goulet,
  • Beatrice Amigues,
  • Jeremy Loehr,
  • Dennis A. Romero,
  • Christophe Fremaux,
  • Philippe Horvath,
  • Yannick Doyon,
  • Christian Cambillau,
  • Sylvain Moineau

DOI
https://doi.org/10.1038/s41467-018-05092-w
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

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Some phages carry genes coding for anti-CRISPR (Acr) proteins that interfere with the activity of bacterial CRISPR-Cas systems. Here, Hynes et al. characterize a new Acr family from streptococcal phages and investigate its potential in genome-editing applications.