Veterinary Research (Jan 2019)

Antiviral activity of itraconazole against type I feline coronavirus infection

  • Tomomi Takano,
  • Misuzu Akiyama,
  • Tomoyoshi Doki,
  • Tsutomu Hohdatsu

DOI
https://doi.org/10.1186/s13567-019-0625-3
Journal volume & issue
Vol. 50, no. 1
pp. 1 – 6

Abstract

Read online

Abstract Feline coronaviruses (FCoVs) are the causative agents of severe systemic disease (feline infectious peritonitis: FIP) in domestic and wild cats. FCoVs have been classified into serotypes I and II. Type I FCoV is the dominant serotype (approximately 70–90%) worldwide. Therefore, it is necessary to provide antiviral agents for type I FCoV infection. In this study, we demonstrated that itraconazole (ICZ), practically used for fungal infections in cats, inhibits the type I FCoV infection. ICZ also exhibited antiviral effect in cells after viral infection, suggesting that ICZ could potentially be used as a therapeutic.