PLoS ONE (Jan 2015)

A Novel Method in the Stratification of Post-Myocardial-Infarction Patients Based on Pathophysiology.

  • Ben He,
  • Heng Ge,
  • Fan Yang,
  • Yujun Sun,
  • Zheng Li,
  • Meng Jiang,
  • Yiting Fan,
  • Jun Pu,
  • Xuedong Shen

DOI
https://doi.org/10.1371/journal.pone.0130158
Journal volume & issue
Vol. 10, no. 6
p. e0130158

Abstract

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ObjectivesWe proposed that the severity of ST-segment elevation myocardial infarction (STEMI) could be classified based on pathophysiological changes.MethodsFirst-STEMI patients were classified within hospitalization. Grade 0: no detectable myocardial necrosis; Grade 1: myocardial necrosis without functional and morphological abnormalities; Grade 2: myocardial necrosis with reduced LVEF; Grade 3: reduced LVEF on the basis of cardiac remodeling; Grade 4: mitral regurgitation additional to the Grade-3 criteria.ResultsOf 180 patients, 1.7, 43.9, 26.1, 23.9 and 4.4% patients were classified as Grade 0 to 4, respectively. The classification is an independent predicator of 90-day MACEs (any death, resuscitated cardiac arrest, acute heart failure and stroke): the rate was 0, 5.1, 8.5, 48.8 and 75% from Grade 0 to 4 (p ConclusionsThe new classification represents an easy and objective method to scale the cardiac detriments for STEMI patients.