Nature Communications (Jul 2017)
Platelet function is modified by common sequence variation in megakaryocyte super enhancers
- Romina Petersen,
- John J. Lambourne,
- Biola M. Javierre,
- Luigi Grassi,
- Roman Kreuzhuber,
- Dace Ruklisa,
- Isabel M. Rosa,
- Ana R. Tomé,
- Heather Elding,
- Johanna P. van Geffen,
- Tao Jiang,
- Samantha Farrow,
- Jonathan Cairns,
- Abeer M. Al-Subaie,
- Sofie Ashford,
- Antony Attwood,
- Joana Batista,
- Heleen Bouman,
- Frances Burden,
- Fizzah A. Choudry,
- Laura Clarke,
- Paul Flicek,
- Stephen F. Garner,
- Matthias Haimel,
- Carly Kempster,
- Vasileios Ladopoulos,
- An-Sofie Lenaerts,
- Paulina M. Materek,
- Harriet McKinney,
- Stuart Meacham,
- Daniel Mead,
- Magdolna Nagy,
- Christopher J. Penkett,
- Augusto Rendon,
- Denis Seyres,
- Benjamin Sun,
- Salih Tuna,
- Marie-Elise van der Weide,
- Steven W. Wingett,
- Joost H. Martens,
- Oliver Stegle,
- Sylvia Richardson,
- Ludovic Vallier,
- David J. Roberts,
- Kathleen Freson,
- Lorenz Wernisch,
- Hendrik G. Stunnenberg,
- John Danesh,
- Peter Fraser,
- Nicole Soranzo,
- Adam S. Butterworth,
- Johan W. Heemskerk,
- Ernest Turro,
- Mikhail Spivakov,
- Willem H. Ouwehand,
- William J. Astle,
- Kate Downes,
- Myrto Kostadima,
- Mattia Frontini
Affiliations
- Romina Petersen
- Department of Haematology, University of Cambridge
- John J. Lambourne
- Department of Haematology, University of Cambridge
- Biola M. Javierre
- Nuclear Dynamics Programme, The Babraham Institute
- Luigi Grassi
- Department of Haematology, University of Cambridge
- Roman Kreuzhuber
- Department of Haematology, University of Cambridge
- Dace Ruklisa
- Department of Haematology, University of Cambridge
- Isabel M. Rosa
- Department of Haematology, University of Cambridge
- Ana R. Tomé
- Department of Haematology, University of Cambridge
- Heather Elding
- Department of Human Genetics, The Wellcome Trust Sanger Institute
- Johanna P. van Geffen
- Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University
- Tao Jiang
- Department of Public Health and Primary Care, Strangeways Research Laboratory, MRC/British Heart Foundation (BHF) Cardiovascular Epidemiology Unit, University of Cambridge
- Samantha Farrow
- Department of Haematology, University of Cambridge
- Jonathan Cairns
- Nuclear Dynamics Programme, The Babraham Institute
- Abeer M. Al-Subaie
- Department of Haematology, University of Cambridge
- Sofie Ashford
- Department of Haematology, University of Cambridge
- Antony Attwood
- Department of Haematology, University of Cambridge
- Joana Batista
- Department of Haematology, University of Cambridge
- Heleen Bouman
- Department of Human Genetics, The Wellcome Trust Sanger Institute
- Frances Burden
- Department of Haematology, University of Cambridge
- Fizzah A. Choudry
- Department of Haematology, University of Cambridge
- Laura Clarke
- European Molecular Biology Laboratory, European Bioinformatics Institute
- Paul Flicek
- European Molecular Biology Laboratory, European Bioinformatics Institute
- Stephen F. Garner
- National Health Service Blood and Transplant (NHSBT)
- Matthias Haimel
- NIHR BioResource-Rare Diseases, University of Cambridge
- Carly Kempster
- Department of Haematology, University of Cambridge
- Vasileios Ladopoulos
- Department of Haematology, University of Cambridge
- An-Sofie Lenaerts
- Department of Surgery, NIHR Cambridge Biomedical Research Centre hIPSC Core Facility, University of Cambridge
- Paulina M. Materek
- Department of Surgery, NIHR Cambridge Biomedical Research Centre hIPSC Core Facility, University of Cambridge
- Harriet McKinney
- Department of Haematology, University of Cambridge
- Stuart Meacham
- Department of Haematology, University of Cambridge
- Daniel Mead
- Department of Human Genetics, The Wellcome Trust Sanger Institute
- Magdolna Nagy
- Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University
- Christopher J. Penkett
- Department of Haematology, University of Cambridge
- Augusto Rendon
- Department of Haematology, University of Cambridge
- Denis Seyres
- Department of Haematology, University of Cambridge
- Benjamin Sun
- Department of Public Health and Primary Care, Strangeways Research Laboratory, MRC/British Heart Foundation (BHF) Cardiovascular Epidemiology Unit, University of Cambridge
- Salih Tuna
- Department of Haematology, University of Cambridge
- Marie-Elise van der Weide
- Department of Haematology, University of Cambridge
- Steven W. Wingett
- Nuclear Dynamics Programme, The Babraham Institute
- Joost H. Martens
- Department of Molecular Biology, Faculty of Science, Radboud University
- Oliver Stegle
- European Molecular Biology Laboratory, European Bioinformatics Institute
- Sylvia Richardson
- Medical Research Council Biostatistics Unit, University of Cambridge
- Ludovic Vallier
- Department of Surgery, Wellcome Trust and MRC Cambridge Stem Cell Institute, University of Cambridge
- David J. Roberts
- Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford
- Kathleen Freson
- Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, University of Leuven
- Lorenz Wernisch
- Medical Research Council Biostatistics Unit, University of Cambridge
- Hendrik G. Stunnenberg
- Department of Molecular Biology, Faculty of Science, Radboud University
- John Danesh
- Department of Human Genetics, The Wellcome Trust Sanger Institute
- Peter Fraser
- Nuclear Dynamics Programme, The Babraham Institute
- Nicole Soranzo
- Department of Haematology, University of Cambridge
- Adam S. Butterworth
- Strangeways Research Laboratory, The National Institute for Health Research (NIHR) Blood and Transplant Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge
- Johan W. Heemskerk
- Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University
- Ernest Turro
- Department of Haematology, University of Cambridge
- Mikhail Spivakov
- Nuclear Dynamics Programme, The Babraham Institute
- Willem H. Ouwehand
- Department of Haematology, University of Cambridge
- William J. Astle
- Department of Haematology, University of Cambridge
- Kate Downes
- Department of Haematology, University of Cambridge
- Myrto Kostadima
- Department of Haematology, University of Cambridge
- Mattia Frontini
- Department of Haematology, University of Cambridge
- DOI
- https://doi.org/10.1038/ncomms16058
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
Numerous genetic variants, including those located in the non-coding regions of the genome, are known to be associated with blood cells traits. Here, Frontini and colleagues investigate their potential regulatory functions using epigenomic data and promoter long-range interactions.
