Direct C–H difluoromethylation of heterocycles via organic photoredox catalysis

Wei Zhang; Xin-Xin Xiang; Junyi Chen; Chen Yang; Yu-Liang Pan; Jin-Pei Cheng; Qingbin Meng; Xin Li

doi:10.1038/s41467-020-14494-8

Nature Communications (Jan 2020)

Direct C–H difluoromethylation of heterocycles via organic photoredox catalysis

Wei Zhang,
Xin-Xin Xiang,
Junyi Chen,
Chen Yang,
Yu-Liang Pan,
Jin-Pei Cheng,
Qingbin Meng,
Xin Li

Affiliations

Wei Zhang: State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University
Xin-Xin Xiang: State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University
Junyi Chen: State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology
Chen Yang: State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University
Yu-Liang Pan: State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University
Jin-Pei Cheng: State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University
Qingbin Meng: State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology
Xin Li: State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University

DOI: https://doi.org/10.1038/s41467-020-14494-8
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 10

Abstract

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Heterocycles containing difluoromethyl groups are molecules with potential application in pharmaceutical, agricultural and materials science. Here, the authors show an organophotocatalytic difluoromethylation of heterocycles using O2 as green oxidant and preliminarily study the products’ bioactivity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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