Nature Communications (Jul 2022)
Adipocyte lysoplasmalogenase TMEM86A regulates plasmalogen homeostasis and protein kinase A-dependent energy metabolism
- Yoon Keun Cho,
- Young Cheol Yoon,
- Hyeonyeong Im,
- Yeonho Son,
- Minsu Kim,
- Abhirup Saha,
- Cheoljun Choi,
- Jaewon Lee,
- Sumin Lee,
- Jae Hyun Kim,
- Yun Pyo Kang,
- Young-Suk Jung,
- Hong Koo Ha,
- Je Kyung Seong,
- James G. Granneman,
- Sung Won Kwon,
- Yun-Hee Lee
Affiliations
- Yoon Keun Cho
- College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University
- Young Cheol Yoon
- College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University
- Hyeonyeong Im
- College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University
- Yeonho Son
- College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University
- Minsu Kim
- College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University
- Abhirup Saha
- College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University
- Cheoljun Choi
- College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University
- Jaewon Lee
- College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University
- Sumin Lee
- College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University
- Jae Hyun Kim
- College of Pharmacy, Kangwon National University
- Yun Pyo Kang
- College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University
- Young-Suk Jung
- Department of Pharmacy, College of Pharmacy, Research Institute for Drug Development, Pusan National University
- Hong Koo Ha
- Department of Urology, Pusan National University Hospital, College of Medicine, Pusan National University
- Je Kyung Seong
- Korea Mouse Phenotyping Center (KMPC), and Laboratory of Developmental Biology and Genomics, College of Veterinary Medicine, Seoul National University
- James G. Granneman
- Center for Molecular Medicine and Genetics, Wayne State University
- Sung Won Kwon
- College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University
- Yun-Hee Lee
- College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University
- DOI
- https://doi.org/10.1038/s41467-022-31805-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Dysregulation of plasmalogen metabolism in adipose tissue is associated with metabolic diseases. Here the authors characterize the role of adipocyte TMEM86A as a lysoplasmalogenase and show its deletion is protective against high fat diet induced metabolic disease, an effect that can be recapitulated by plasmenyl lysophosphatidylethanolamine 18:0 supplementation.
