Zhongliu Fangzhi Yanjiu (Nov 2020)

Mechanism and Strategy of Combination Immunotherapy in Integrated Tumor Therapy

  • WANG Zhigao,
  • FANG Qiqi,
  • GAO Fei,
  • LI Qingxia

Journal volume & issue
Vol. 47, no. 11
pp. 818 – 816


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With the in-depth study of tumor immune microenvironment, immune checkpoint inhibitors represented by PD-1/PD-L1 inhibitors have achieved promising results in tumor treatment. However, the treatment response rate is low with immunotherapy alone. Integrative therapy is the development trend of tumor therapy. The combined treatment strategies of PD-1/PD-L1 inhibitors with chemotherapy, radiotherapy, TKI, antiangiogenic drugs, etc. are being actively explored. This paper reviews the mechanism and progress of related combined regimens.