Nature Communications (May 2021)
Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity
- Chenxu Yan,
- Tianshu Zeng,
- Kailun Lee,
- Max Nobis,
- Kim Loh,
- Luoning Gou,
- Zefeng Xia,
- Zhongmin Gao,
- Mohammed Bensellam,
- Will Hughes,
- Jackie Lau,
- Lei Zhang,
- Chi Kin Ip,
- Ronaldo Enriquez,
- Hanyu Gao,
- Qiao-Ping Wang,
- Qi Wu,
- Jody J. Haigh,
- D. Ross Laybutt,
- Paul Timpson,
- Herbert Herzog,
- Yan-Chuan Shi
Affiliations
- Chenxu Yan
- Neuroscience Division, Garvan Institute of Medical Research, St Vincent’s Hospital
- Tianshu Zeng
- Wuhan Union Hospital, Huazhong University of Science and Technology
- Kailun Lee
- Neuroscience Division, Garvan Institute of Medical Research, St Vincent’s Hospital
- Max Nobis
- Invasion and Metastasis Lab, Cancer Division, Garvan Institute of Medical Research, St Vincent’s Hospital
- Kim Loh
- Neuroscience Division, Garvan Institute of Medical Research, St Vincent’s Hospital
- Luoning Gou
- Wuhan Union Hospital, Huazhong University of Science and Technology
- Zefeng Xia
- Wuhan Union Hospital, Huazhong University of Science and Technology
- Zhongmin Gao
- Diabetes and Metabolism Division, Garvan Institute of Medical Research, St Vincent’s Hospital
- Mohammed Bensellam
- Diabetes and Metabolism Division, Garvan Institute of Medical Research, St Vincent’s Hospital
- Will Hughes
- Diabetes and Metabolism Division, Garvan Institute of Medical Research, St Vincent’s Hospital
- Jackie Lau
- Neuroscience Division, Garvan Institute of Medical Research, St Vincent’s Hospital
- Lei Zhang
- Neuroscience Division, Garvan Institute of Medical Research, St Vincent’s Hospital
- Chi Kin Ip
- Neuroscience Division, Garvan Institute of Medical Research, St Vincent’s Hospital
- Ronaldo Enriquez
- Neuroscience Division, Garvan Institute of Medical Research, St Vincent’s Hospital
- Hanyu Gao
- Diabetes and Metabolism Division, Garvan Institute of Medical Research, St Vincent’s Hospital
- Qiao-Ping Wang
- School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University
- Qi Wu
- Diabetes and Metabolism Division, Garvan Institute of Medical Research, St Vincent’s Hospital
- Jody J. Haigh
- Research Institute in Oncology and Hematology, Department of Pharmacology and Therapeutics, University of Manitoba
- D. Ross Laybutt
- Diabetes and Metabolism Division, Garvan Institute of Medical Research, St Vincent’s Hospital
- Paul Timpson
- Invasion and Metastasis Lab, Cancer Division, Garvan Institute of Medical Research, St Vincent’s Hospital
- Herbert Herzog
- Neuroscience Division, Garvan Institute of Medical Research, St Vincent’s Hospital
- Yan-Chuan Shi
- Neuroscience Division, Garvan Institute of Medical Research, St Vincent’s Hospital
- DOI
- https://doi.org/10.1038/s41467-021-22925-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 20
Abstract
Neuropeptide Y signalling in the periphery contributes to the regulation of metabolic and energy homeostasis. Here the authors show that blocking Y1R signalling in peripheral tissues using the selective antagonist BIBO3304 ameliorates diet-induced obesity and improves whole-body glucose metabolism.
