Radboud University Nijmegen, Nijmegen, Netherlands; Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behavior, Nijmegen, Netherlands; Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, Netherlands
Thomas Wolfers
Radboud University Nijmegen, Nijmegen, Netherlands; Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behavior, Nijmegen, Netherlands; Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, Netherlands
Peter Mulders
Radboud University Nijmegen, Nijmegen, Netherlands; Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behavior, Nijmegen, Netherlands; Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, Netherlands; Department of Psychiatry, Radboud University Medical Center, Nijmegen, Netherlands
Christian F Beckmann
Radboud University Nijmegen, Nijmegen, Netherlands; Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behavior, Nijmegen, Netherlands; Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, Netherlands; Department of Psychiatry, Radboud University Medical Center, Nijmegen, Netherlands; Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), University of Oxford, Oxford, United Kingdom
We perform a comprehensive integrative analysis of multiple structural MR-based brain features and find for the first-time strong evidence relating inter-individual brain structural variations to a wide range of demographic and behavioral variates across a large cohort of young healthy human volunteers. Our analyses reveal that a robust ‘positive-negative’ spectrum of behavioral and demographic variates, recently associated to covariation in brain function, can already be identified using only structural features, highlighting the importance of careful integration of structural features in any analysis of inter-individual differences in functional connectivity and downstream associations with behavioral/demographic variates.