Nature Communications (Sep 2021)

Schizophrenia, autism spectrum disorders and developmental disorders share specific disruptive coding mutations

  • Elliott Rees,
  • Hugo D. J. Creeth,
  • Hai-Gwo Hwu,
  • Wei J. Chen,
  • Ming Tsuang,
  • Stephen J. Glatt,
  • Romain Rey,
  • George Kirov,
  • James T. R. Walters,
  • Peter Holmans,
  • Michael J. Owen,
  • Michael C. O’Donovan

DOI
https://doi.org/10.1038/s41467-021-25532-4
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 9

Abstract

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Overlapping genes have been implicated in schizophrenia and neurodevelopmental disorders. Here, the authors overlap de novo variants in the two types of disorders and find variants in these genes with the same functional effect and in some cases the same specific variants.