Journal of Laboratory Medicine (Jun 2024)

Attention should be paid to false-positive results due to heterophilic antibodies interfering with Abbott high-sensitivity cardiac troponin I assay

  • Liu Weiping,
  • Long Xia,
  • Chen Lulu,
  • Yang Kailan

DOI
https://doi.org/10.1515/labmed-2023-0131
Journal volume & issue
Vol. 48, no. 3
pp. 137 – 140

Abstract

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In recent years, chemiluminescent microparticle immunoassay (CMIA) has been widely used for determination of high-sensitivity troponin I (hs-cTnI). However, a CMIA analysis is usually affected by the presence of some endogenous or exogenous substances. This case-report aims to unveil the essence of the reoccurrence of false-positive results due to heterophilic antibodies interference with Abbott high-sensitivity cardiac troponin I assay, although the assay method applied a chimeric antibody.

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