Salud Pública de México (Jun 2019)

Characteristics of non-small cell lung cancer: Differences by sex and hormonal status in a Mexican population

  • Vianey Rodríguez-Lara,
  • Laura Alejandra Ramírez-Tirado,
  • Feliciano Barrón,
  • Zyanya Lucía Zatarain-Barrón,
  • Diana Flores-Estrada,
  • Oscar Arrieta

DOI
https://doi.org/10.21149/10094
Journal volume & issue
Vol. 61, no. 3, may-jun
pp. 265 – 275

Abstract

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Objective. To analyze the differences in the clinico-patho­logical and molecular characteristics of non-small cell lung cancer (NSCLC) as well as the clinical outcome of patients by sex and hormonal status. Materials and methods. We performed a retrospective study among 1 104 NSCLC patients. Clinic-pathologic data was recorded and survival outcomes were compared between male and female sex patients, and further by pre and postmenopausal status in fe­males. Results. Women were significantly more likely to be non-smokers (p<0.001), had higher frequency of wood-smoke exposure (p<0.001), EGFR-sensitizing mutations (p<0.001), had better performance status (p=0.020) and had a better overall survival (OS) compared to men (p=0.021). Differences were found also by hormonal status, postmenopausal women had a longer OS compared to premenopausal women (31.1 vs. 19.4 months p=0.046). Conclusion. Our results support the differences in lung cancer presentation by sex and also by hormonal status.

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