Structural basis for amino acid transport by the CAT family of SLC7 transporters

Katharina E. J. Jungnickel; Joanne L. Parker; Simon Newstead

doi:10.1038/s41467-018-03066-6

Nature Communications (Feb 2018)

Structural basis for amino acid transport by the CAT family of SLC7 transporters

Katharina E. J. Jungnickel,
Joanne L. Parker,
Simon Newstead

Affiliations

Katharina E. J. Jungnickel: Department of Biochemistry, University of Oxford
Joanne L. Parker: Department of Biochemistry, University of Oxford
Simon Newstead: Department of Biochemistry, University of Oxford

DOI: https://doi.org/10.1038/s41467-018-03066-6
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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Cationic amino acid transporters (CATs) belong to the physiologically important solute carrier (SLC) 7 family. Here, the authors present the structure of the mammalian CAT transporter homologue Geobacillus kaustophilus GkApcT, which reveals how arginine is recognized, and propose a model for proton-coupled amino acid transport.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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