Revista CENIC Ciencias Químicas (May 2016)
Gassed biochemical reactor
Abstract
Gassed biochemical reactor called Gassed reactor from now on is equipped by pneumatic mixing device per substitution of the electric motors and magnetic drivers or the aseptic mechanical seal to warrant asepsis and isolation conditions in biochemical applications; in particular, Gassed reactor is distinguished by higher mass-transfer rates in aerobic biochemical processes that take place under the enriched gas atmosphere of the reactor’s chamber. A maximum working gas-flow expands to the set allowable levels of liquid turbulence of the reactor’s chamber by experimental tests and the maximum reactor-scale to the set allowable value is found by mathematical simulation. The software and the user-interface are conceived to accomplish the reactor’s design and estimate the technical performance to the mixing processes on gas-liquid systems. Gassed reactor supports different geometrical rates to the standard reactor with single impeller at the slender vessels showing arrangements of impellers of different sizes; the sterile gas for the reactor’s operation is produced to the compression unit itself per substitution of the regular sterilization procedures. Gassed reactor is distinguished by mechanical breaking of the unwanted foams to avoiding the use of chemicals, the safe extraction of samplings and yields pressurizing the reactor’s chamber and the supply of suspensions on the working gas-stream; the reactor constitutes a new technological alternative of low-cost for small pharmaceutical productions, the works on labs and research purposes; significant technical and economical profits at reactors layouts are foreseen.
