Recent advances on the role of G-protein-coupled receptors in kidney diseases

Abstract

The G-protein-coupled receptors (GPCRs) are widely expressed in many cell types and participate in various cellular biological processes. Several studies have shown that GPCRs-mediated signaling pathways play significant roles in maintaining renal development, regulating renal physiological function, and in the pathogenesis of renal diseases. In this review, we have described the characteristics and function of GPCRs-related pathways, especially the adhesion GPCRs (aGPCRs), cannabinoid receptors (CB), and lysophosphatidic acid receptors (LPAR) in the field of kidney diseases. Hopefully, this review could enhance the understanding of GPCRs function and shed light on potential therapeutic targets for kidney disease treatment.

Keywords

• g-protein-coupled receptors (gpcrs)
• kidney diseases
• adhesion gpcrs
• cannabinoid receptors
• lysophosphatidic acid receptors