Research progress of RNF180 in gastric cancer

Zhang Yating; Wei Yucai; Li Yumin

doi:10.12287/j.issn.2096-8965.20220102

生物医学转化 (Mar 2022)

Research progress of RNF180 in gastric cancer

Zhang Yating,
Wei Yucai,
Li Yumin

Affiliations

Zhang Yating: Second Clinical Medical College of Lanzhou University, Lanzhou 730000, Gansu, China; Gansu Provincial Key Laboratory of Gastrointestinal Tumors, Lanzhou 730030, Gansu, China
Wei Yucai: Second Clinical Medical College of Lanzhou University, Lanzhou 730000, Gansu, China; Gansu Provincial Key Laboratory of Gastrointestinal Tumors, Lanzhou 730030, Gansu, China
Li Yumin: Second Clinical Medical College of Lanzhou University, Lanzhou 730000, Gansu, China; Gansu Provincial Key Laboratory of Gastrointestinal Tumors, Lanzhou 730030, Gansu, China

DOI: https://doi.org/10.12287/j.issn.2096-8965.20220102
Journal volume & issue: Vol. 3, no. 1
pp. 13 – 19-45

Abstract

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RNF180 is a type of ring finger protein with ubiquitin ligase activity, which can affect various physiological processes such as cell proliferation, differentiation and apoptosis by participating in the ubiquitinproteasome system. Studies have shown that RNF180 is mostly low-expressed in tumors, which can inhibit the proliferation and invasion of gastric cancer cells, and affect the lymph node metastasis and prognosis of gastric cancer. The gene expression silencing caused by the methylation of the promoter of RNF180 is the main reason for the low expression of RNF180 protein in tumors. Important methylation sites are related to precancerous lesions, lymph node metastasis of gastric cancer and patient prognosis. Therefore, RNF180 has the potential to become a biomarker of gastric cancer tumors.

Published in 生物医学转化

ISSN: 2096-8965 (Print)
Publisher: Lanzhou University Press
Country of publisher: China
LCC subjects: Medicine; Technology: Chemical technology: Biotechnology
Website: http://swyxzh.ijournals.cn/swyxzhen/home

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Abstract

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