Проблемы особо опасных инфекций (Apr 2008)

Phenotypic Peculiarities of Pathogenic <i>Burkholderia</i> Mutants Resistant to Fluoroquinolones and Cephalosporins

  • E. V. Kalinkina,
  • N. P. Ageeva,
  • O. A. Merinova,
  • D. A. Loboiko,
  • D. V. Viktorov,
  • L. K. Merinova

DOI
https://doi.org/10.21055/0370-1069-2008-2(96)-32-35
Journal volume & issue
Vol. 0, no. 2(96)
pp. 32 – 35

Abstract

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Examined were phenotypic peculiarities of mutants of Burkholderia phylogenetically-related pathogenic species (B. pseudomallei, B. mallei, B. cepacia) resistant to fluoroquinolones and cephalosporins. It was shown that strains with PfxR (OfxR), CfzR markers acquire high multi-drug resistance to antibiotics of different classes. Strain resistance changes under blocking influence of verapamil - inhibitor of calcium membrane channels. Mutant strains differ in production of extracellular enzymes (proteases, lecithinase, lipase) and virulence.

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