Management of the Elderly Patients with High-Grade Serous Ovarian Cancer in the REAL-WORLD Setting

Michalis Liontos; Alkistis Papatheodoridi; Angeliki Andrikopoulou; Nikolaos Thomakos; Dimitrios Haidopoulos; Alexandros Rodolakis; Flora Zagouri; Aristotelis Bamias; Meletios-Athanasios Dimopoulos

doi:10.3390/curroncol28020110

Current Oncology (Mar 2021)

Management of the Elderly Patients with High-Grade Serous Ovarian Cancer in the REAL-WORLD Setting

Michalis Liontos,
Alkistis Papatheodoridi,
Angeliki Andrikopoulou,
Nikolaos Thomakos,
Dimitrios Haidopoulos,
Alexandros Rodolakis,
Flora Zagouri,
Aristotelis Bamias,
Meletios-Athanasios Dimopoulos

Affiliations

Michalis Liontos: Department of Clinical Therapeutics, Alexandra General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece
Alkistis Papatheodoridi: Department of Clinical Therapeutics, Alexandra General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece
Angeliki Andrikopoulou: Department of Clinical Therapeutics, Alexandra General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece
Nikolaos Thomakos: Department of Obstetrics and Gynaecology, Alexandra General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece
Dimitrios Haidopoulos: Department of Obstetrics and Gynaecology, Alexandra General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece
Alexandros Rodolakis: Department of Obstetrics and Gynaecology, Alexandra General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece
Flora Zagouri: Department of Clinical Therapeutics, Alexandra General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece
Aristotelis Bamias: Department of Clinical Therapeutics, Alexandra General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece
Meletios-Athanasios Dimopoulos: Department of Clinical Therapeutics, Alexandra General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece

DOI: https://doi.org/10.3390/curroncol28020110
Journal volume & issue: Vol. 28, no. 2
pp. 1143 – 1152

Abstract

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Treatment of elderly patients with neoplasia is challenging. Age is a known prognostic factor in ovarian cancer but the optimal treatment of elderly patients has not been determined. We undertook a retrospective analysis to determine clinical practice in advanced-stage ovarian cancer patients older than 70 years of age. Methods: Medical records of women with high-grade serous ovarian cancer, stage III and IV were retrospectively analyzed. Results: A total of 735 patients were identified with a median age of 61.5 years. 22.4% among them were older than 70 years of age at diagnosis. First-line Progression-Free Survival (PFS) and Overall Survival (OS) were significantly worse in elderly patients in comparison to the younger ones [mPFS 11.3 months vs. 14.8 months, (p p Conclusions: Elderly ovarian cancer patients have a worse prognosis. Comprehensive geriatric assessment should be performed for the optimal treatment of these patients.

Published in Current Oncology

ISSN: 1198-0052 (Print); 1718-7729 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.mdpi.com/journal/curroncol

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