Nature Communications (Feb 2017)
DEK-targeting DNA aptamers as therapeutics for inflammatory arthritis
- Nirit Mor-Vaknin,
- Anjan Saha,
- Maureen Legendre,
- Carmelo Carmona-Rivera,
- M Asif Amin,
- Bradley J. Rabquer,
- Marta J. Gonzales-Hernandez,
- Julie Jorns,
- Smriti Mohan,
- Srilakshmi Yalavarthi,
- Dave A. Pai,
- Kristine Angevine,
- Shelley J. Almburg,
- Jason S. Knight,
- Barbara S. Adams,
- Alisa E. Koch,
- David A. Fox,
- David R. Engelke,
- Mariana J. Kaplan,
- David M. Markovitz
Affiliations
- Nirit Mor-Vaknin
- Department of Internal Medicine, Division of Infectious Diseases, University of Michigan
- Anjan Saha
- Department of Internal Medicine, Division of Infectious Diseases, University of Michigan
- Maureen Legendre
- Department of Internal Medicine, Division of Infectious Diseases, University of Michigan
- Carmelo Carmona-Rivera
- Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases
- M Asif Amin
- Department of Internal Medicine, Division of Rheumatology, University of Michigan
- Bradley J. Rabquer
- Department of Internal Medicine, Division of Rheumatology, University of Michigan
- Marta J. Gonzales-Hernandez
- Department of Internal Medicine, Division of Infectious Diseases, University of Michigan
- Julie Jorns
- Department of Pathology, University of Michigan
- Smriti Mohan
- Department of Pediatrics and Communicable Diseases, Division of Pediatric Rheumatology, University of Michigan
- Srilakshmi Yalavarthi
- Department of Internal Medicine, Division of Rheumatology, University of Michigan
- Dave A. Pai
- Department of Biological Chemistry, University of Michigan
- Kristine Angevine
- Department of Biological Chemistry, University of Michigan
- Shelley J. Almburg
- Microscopy & Image – Analysis Laboratory, University of Michigan
- Jason S. Knight
- Department of Internal Medicine, Division of Rheumatology, University of Michigan
- Barbara S. Adams
- Department of Internal Medicine, Division of Infectious Diseases, University of Michigan
- Alisa E. Koch
- Department of Internal Medicine, Division of Rheumatology, University of Michigan
- David A. Fox
- Department of Internal Medicine, Division of Rheumatology, University of Michigan
- David R. Engelke
- Department of Biological Chemistry, University of Michigan
- Mariana J. Kaplan
- Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases
- David M. Markovitz
- Department of Internal Medicine, Division of Infectious Diseases, University of Michigan
- DOI
- https://doi.org/10.1038/ncomms14252
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
DEK is a secreted protein abundant in the synovia of patients with juvenile idiopathic arthritis. Here the authors show DEK is important for neutrophil extracellular trap formation and joint inflammation, and demonstrate therapeutic efficacy of DEK-targeting aptamers in a mouse model of arthritis.
