Nature Communications (Apr 2020)
Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance
- Kay H. M. Roumans,
- Lucas Lindeboom,
- Pandichelvam Veeraiah,
- Carlijn M. E. Remie,
- Esther Phielix,
- Bas Havekes,
- Yvonne M. H. Bruls,
- Martijn C. G. J. Brouwers,
- Marcus Ståhlman,
- Marjan Alssema,
- Harry P. F. Peters,
- Renée de Mutsert,
- Bart Staels,
- Marja-Riitta Taskinen,
- Jan Borén,
- Patrick Schrauwen,
- Vera B. Schrauwen-Hinderling
Affiliations
- Kay H. M. Roumans
- Department of Nutrition and Movement Sciences, Maastricht University
- Lucas Lindeboom
- Department of Nutrition and Movement Sciences, Maastricht University
- Pandichelvam Veeraiah
- Department of Nutrition and Movement Sciences, Maastricht University
- Carlijn M. E. Remie
- Department of Nutrition and Movement Sciences, Maastricht University
- Esther Phielix
- Department of Nutrition and Movement Sciences, Maastricht University
- Bas Havekes
- Department of Internal Medicine, Division of Endocrinology and Metabolic Disease, Maastricht University Medical Center
- Yvonne M. H. Bruls
- Department of Nutrition and Movement Sciences, Maastricht University
- Martijn C. G. J. Brouwers
- Department of Internal Medicine, Division of Endocrinology and Metabolic Disease, Maastricht University Medical Center
- Marcus Ståhlman
- Department of Molecular and Clinical Medicine, University of Gothenburg, and Sahlgrenska University Hospital
- Marjan Alssema
- Unilever Food Innovation Center
- Harry P. F. Peters
- Unilever Food Innovation Center
- Renée de Mutsert
- Department of Clinical Epidemiology, Leiden University Medical Center
- Bart Staels
- Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille
- Marja-Riitta Taskinen
- Research Program, Unit Clinical and Molecular Metabolism, University of Helsinki
- Jan Borén
- Department of Molecular and Clinical Medicine, University of Gothenburg, and Sahlgrenska University Hospital
- Patrick Schrauwen
- Department of Nutrition and Movement Sciences, Maastricht University
- Vera B. Schrauwen-Hinderling
- Department of Nutrition and Movement Sciences, Maastricht University
- DOI
- https://doi.org/10.1038/s41467-020-15684-0
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
Hepatic steatosis is associated with poor cardiometabolic health, with de novo lipogenesis (DNL) contributing to hepatic steatosis and subsequent insulin resistance. Here, the authors use 1H-MRS methodology to show hepatic SFA fraction is a measure of DNL and specifically may hamper hepatic insulin sensitivity.
